Paddlers begin their journey from a wide brackish bay, but as they head north, the creek narrows and wide marshy expanses give way to shoreline trees. Historically, a large indigenous Native American habitation was nestled around the Spruce Creek basin. A prehistoric earthen works, the Spruce Creek Mound, is located on the creek. The site functioned as a major ceremonial and political center for the Timucua Indians. Lesser mounds are scattered throughout surrounding areas.
Due to its scenic nature, Spruce Creek is one of Florida's state-designated paddling trails.